Darkspace usually refers to the intergalactic void that exists between celestial galaxies.

It may refer to:

• DarkSpace, a computer game

• Darkspace, a Swiss ambient black metal band

• "Darkspace", a song by Morten Harket from Letter from Egypt

• "Darkspace", a short story by Robert F. Young

• Dark Space, a 2013 film

• Dark Space, a role-playing game supplement for Space Master by Monte Cook, published by Iron Crown Enterprises