Efe or EFE may refer to:

• Efe (name), male given name and surname

People

• Efé people, an ethnic group in the Democratic Republic of the Congo

• Efe (zeybek), leaders of Turkish outlaws and soldiers

• Efe (musician) (born 1993), Nigerian musician and media personality

Science and engineering

• 2-oxoglutarate dioxygenase (ethylene-forming)

• 2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)

• Early fuel evaporator

• Einstein field equations

• Endocardial fibroelastosis, a heart condition in young children

• External field effect in Modified Newtonian dynamics

Other uses

• Efe, one of the nine default skins in the game Minecraft.

• EFE, a Spanish news agency

• Edelman Financial Engines, a financial planning and investment advisory company

• Efe language

• Empresa de Ferrocarriles Ecuatorianos, the national railway of Ecuador

• Empresa de los Ferrocarriles del Estado, the national railway of Chile

• Exclusive First Editions, a British die-cast bus model manufacturer

• Trofeo EFE, a Spanish football award