ISCO or Isco may refer to:

• Innermost stable circular orbit, the smallest stable orbit around a black hole

• International Standard Classification of Occupations, an International Labour Organization (ILO) classification structure

• Information Sharing Customer Outreach, a directorate within the office of the Chief Information Officer (CIO) under the Office of the Director of National Intelligence (ODNI) of the U.S.A.

• In situ chemical oxidation, a way to remediate organic contamination below the ground surface by direct injection of oxidants

• Isco (born 1992), Spanish footballer

• ISCO (videogame developer) (), Japan

• ISCO Optics of Göttingen, Sweden, maker of lenses etc. such as Iscorama

• ISCO Championship, a golf tournament in the United States

See also