PLB or Personal Locator Beacon is a type of distress radiobeacon.

PLB may also refer to:

• Physics Letters B, a scientific journal covering nuclear physics, Particle physics, and astrophysics.

• Processor Local Bus, a bus used for IBM's PowerPC processors

• Programming Language for Business

• Public light bus, a form of public transport in Hong Kong

• Pursed lip breathing, a breathing technique used in medicine

• Premier League of Belize the highest competitive football league in Belize

• Clinton County Airport's IATA code

• Phospholipase B

• Phospholamban