Prison Break is a 2005–2017 American TV serial drama

Prison break may refer to:

• Prison breakout, a prison escape

Film and television

• Prison Break: The Final Break, a 2009 American TV film, part of the Prison Break TV franchise

• Prison Break (film), a 1938 American crime drama

• Prison Break (Amphibia), a 2019 episode of American animated TV series Amphibia

See also

• Jailbreak (disambiguation)