G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.

Ligand

Inverse Agonist

• Cannabidiol

• Solangepras (solengepras; CVN-424)

Evolution

Sequence homologyParalogues to GPR6 genegene

Source:

• GPR3

• GPR12

• S1PR5

• S1PR1

• CNR1

• S1PR2

• LPAR2

• CNR2

• MC1R

• S1PR3

• S1PR4

• GPR119

• MC3R

• MC4R

• MC5R

• LPAR1

• LPAR3

• MC2R

See also

• Lysophospholipid receptor

References

Further reading

External links