Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene. LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.

Interactions

LPAR2 has been shown to interact with TRIP6.

Evolution

Sequence homologyParalogues

Source:

• LPAR1

• LPAR3

• S1PR1

• S1PR5

• S1PR4

• S1PR2

• S1PR3

• GPR6

• GPR3

• GPR12

• MC4R

• MC5R

• CNR1

• MC3R

• CNR2

• MC1R

• GPR119

• MC2R

See also

• Lysophospholipid receptor

References

Further reading

External links